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The pharmacological rationale rests on the concentration-dependent bactericidal activity of aminoglycosides, whereby higher peak-to-MIC ratios enhance killing efficacy, combined with the saturable nature of aminoglycoside uptake into renal tubular and cochlear hair cells: prolonged drug-free intervals between doses may reduce cumulative intracellular drug loading and thereby the potential for organ toxicity ( Meta-analytic evidence consistently supports extended-interval dosing as at least equivalent to multiple daily dosing in efficacy and safety

Services on Demand Journal Article Indicators Cited by SciELO Access statistics Related links Similars in SciELO Share Revista Colombiana de Obstetricia y Ginecologa Print version ISSN 0034-7434 On-line version ISSN 2463-0225 Rev Colomb Obstet Ginecol vol.53 no.4 Bogot Oct./Dec

Surv Ophthalmol 62:462492