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Description

This selective effect of the MSO/CB839 combination contrasts sharply with the general toxicity observed with direct pharmacological inhibition of upstream regulators like FOXO1 (using AS1842856), which non-selectively reduced the viability of all cell lines, including parental wild-type cells (Appendix Fig

[Abstract]2023 Nov;14(31):3089-3096

They are produced by natural metabolic processes and external factors like pollution, UV rays, and poor diet

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