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Additionally, during this period, a variety of antiviral drugs targeting different viruses emerged, such as the combination of interferon (IFN) and ribavirin for the treatment of hepatitis C virus (HCV), providing effective therapeutic options for a broader spectrum of viral diseases

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Because creatinine is cleared almost exclusively by glomerular filtration, its concentration in blood is a central biomarker for diagnosing acute kidney injury, chronic renal failure, glomerulonephritis, and dehydration [185-187]