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In another analysis of five randomized controlled trials involving over 700 subjects with venous ulcers, treatment with the diosmin preparation combined with conventional therapy increased the chances of ulcer healing by 32% at six months compared with conventional therapy alone (Coleridge-Smith 2005)

A decrease in temperature below 4 C also causes slight expansion and water expands the most when it freezes, resulting in a decrease in density

Patel M, Yarlagadda V, Adedoyin O, Saini V, Assimos DG, Holmes RP, Mitchell T (2018) Oxalate induces mitochondrial dysfunction and disrupts redox homeostasis in a human monocyte derived cell line