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The importance of ROS on NF-B activation is further supported by studies demonstrating that activation of NF-B by nearly all stimuli can be blocked by antioxidants, such as L-cysteine, N-acetylcysteine (NAC), thiols, green tea polyphenols, and vitamin E [185, 186], although this might be not very specific because antioxidants have multiple targets [187]

55 Thus, it appears that relevant LPO sufficient to cause cell death is only observed under conditions that make the animals highly susceptible to LPO, but not under normal conditions