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[1] Bi-Amino Injections clinical rationale draws on pharmacokinetic evidence that intravenous arginine produces a sharp plasma peak followed by biphasic clearance, whereas citrulline bypasses splanchnic arginase activity, undergoes efficient renal conversion back to arginine, and sustains substrate availability for nitric-oxide synthase several hours beyond the initial infusion

Discussion Progressive intracellular accumulation of SCMAS, starting within the lysosomes, is a hallmark of CLN3 Batten disease [42]

When these proximal and distal joints are not adequately stabilized, it further increases the likelihood of abnormal knee mechanics

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