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24 These substances promote inflammation as well as sensitize nociceptive pathways, leading to increased pain sensitivity, known as hyperalgesia, and pain from normally non-painful stimuli, termed allodynia

These iNs retained the heteroplasmy mutation load from the parent fibroblast and showed features of matured neurons

While existing research has identified hyperuricemia involvement in numerous biological processes and signaling pathways, the precise mechanisms connecting elevated UA levels to disease etiology remain to be fully elucidated

Treatment with RY-A significantly improved these pathological changes and attenuated the CCH-induced neural tissue damage