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However, DAMPs-mediated signalling can also generate detrimental effects, particularly when a massive release of pro-inflammatory DAMPs from dying cells causes more cells to die: a situation that strongly contributes to the CD4+ T cell depletion in patients infected with HIV-1 (63, 64), reviewed in (65)

Clinical Benefits of Basic Emollient Therapy for the Management of Patients With Xerosis Cutis

And the result provided similar events

The droplet emulsion was thermally cycled on C1000 Touch Thermal Cycler (Bio-Rad Laboratories, CA, USA) instrument, starting with incubation at 95 C for 10 min, followed by 40 cycles of 94 C for 30 s, 60 C for 60 s, 10 min incubation at 98 C and a final hold at 4 C