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Description

DOI: 10.1038/s41467-017-01114-1 Formulation strategies for therapeutic peptide stability pH, ionic strength, co-solvency

The second position of its N-terminus is glycine (alanine in GLP-1), which is not easily degraded by the DPP-4 enzyme

Each freeze-thaw cycle stresses the peptide in solution and can cause aggregation, the process by which peptide molecules clump together and lose biological activity