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doi: 10.1016/j.talanta.2019.120315

Once lipid peroxidation products reach a critical threshold, they disrupt cellular and mitochondrial membranes, impairing basic functions such as material transport and energy conversion, and ultimately leading to cell death [100]

Intraperitoneally administered costus after-derived AgNPs at 200 mg/kg significantly decreased testicular lipid peroxidation (MDA) levels and increased endocrine restoration with less oxidative stress, restoring testosterone levels from 2.1 ng/mL in diabetic controls to 4.5 ng/mL ( Table 4 )

Patients will be qualified for trial according to the inclusion and exclusion criteria of drug program B.55 published by National Health Found to be eligible for the trial, subjects must meet all of the inclusion criteria and none of the exclusion criteria, as stated below