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On the other hand, in the chronic hyperglycemia condition in diabetes, O-GlcNAc transferase reduces the transcription of SERCA2, which results in decreased calcium reuptake and impaired relaxation (55)

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Inflammatory cytokines can cross the blood-brain barrier, activating microglial cells (the brain's resident immune cells)

For example, IL-10 receptor mutations result in a severe, early onset colitis, which has been successfully treated by bone marrow transplant [115, 116]