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Interestingly, berberine has been found to promote the ubiquitination of insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) through the E3 ubiquitin ligase TRIM21

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doi: 10.1038/s41598-022-09082-3, 22

Long-Term duloxetine treatment normalizes altered brain-derived neurotrophic factor expression in serotonin transporter knockout rats through the modulation of specific neurotrophin isoforms