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Whilst humans have orthologues of the enzymes PCK, MEZ and PCA, the absence of PPDK in vertebrates identifies this enzyme as a promising anti-microbial drug target

its also essential for red blood cell formation

These residual empty capsids (empty capsid B) were cleared by CEX polishing chromatography to a similar level as the GSH elution from 37C batches, with only a faint VP0 band detectable by SDS-PAGE (Supplementary Figure S7C)