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Moderate/high concentrations Prostration, tremors, cardiac arrhythmia, seizures, stupor, paralysis, respiratory coma, depression, respiratory arrest, cardiac arrest, collapse [9]

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But...the fact remains that if you have symptoms which could be due to B12 deficency, then more frequent injections are required - thought the UK prescribing guidelines don't appear flexible enough to actually enable this (after loading doses and neurological regime - if needed - the only options seem to be eight weekly or three monthly

But what about those with a less common MTHFR mutation A1298C