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Kopetz S, Yoshino T, Kim TW, Wasan HS, Cutsem EV, Ciardiello F, Maughan TS, Eng C, Yaeger R, Desai J, Zhang X, Usari T, Mori A, Tabernero J

Simvastatin inhibits PD-L1 via ILF3 to induce ferroptosis in gastric cancer cells

In this study, we further examined the mechanism of Ca 2+ -sensitive reduction of the ER lumen by real-time measurements using Grx1-roGFP1-iE ER and HyPer-ER and found evidence for a Ca 2+ depletion-driven GSH transport process through the ER membrane

Although the standard diagnostic approach relies on clinical data, radiological findings, and histopathology, a significant number of cases remain unclassified even after exhaustive investigations involving blood tests, advanced imaging, endoscopy, and molecular evaluation