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This is for several reasons, enumerated in detail in a recent review [1], partly relating to problems with drug uptake into the worm

On the other hand, inorganic anion transport was enriched in S

Ling H, Pickard K, Ivan C, Isella C, Ikuo M, Mitter R, Spizzo R, Bullock MD, Braicu C, Pileczki V, Vincent K, Pichler M, Stiegelbauer V, Hoefler G, Almeida MI, Hsiao A, Zhang X, Primrose JN, Packham GK, Liu K, Bojja K, Gaf R, Xiao L, Rossi S, Song JH, Vannini I, Fanini F, Kopetz S , Zweidler-McKay P, Wang X, Ionescu C, Irimie A, Fabbri M, Lanza G, Hamilton SR, Berindan-Neagoe I, Medico E, Mirnezami AH, Calin GA, Nicoloso MS

Therapeutic strategies that modulate apoptosis may interfere with or promote regulated necrosis