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Storage Lyophilizate (dry powder before reconstitution) 2 years at 20 C (freezer) 12 months at 28 C (refrigerator) Only short-term (up to 14 days) at room temperature, Cagrilintide is more sensitive to aggregation at higher temperatures Protect from light and moisture After reconstitution (peptide in solution with bacteriostatic water) Up to 21 days at 28 C , protected from light Cagrilintide has slightly shorter shelf life than Semaglutide because of its amyloid tendency Practical storage rules Allow the vial to warm to room temperature (1520 min) before opening

B., Milavic, M., Sikiric, S., Stilinovic, I., Simeon, P., Knezevic, M., Kolak, T., Tepes, M., Simonji, K., Strbe, S., Gabaj, N

49,50 Glutamate is the main neurotransmitter for increasing nerve excitability, while gamma-aminobutyric acid (GABA) is the main inhibitor of nerve signal transmission

However, comprehensive safety data for the specific triple combination in humans is limited