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FIGURE 5 Effect of Melatonin on Expression Levels of Genes Related to the Antioxidant Response under Oxidative Stress Expression of selected genes implicated in endogenous antioxidant defense was also determined at 45 and 120 min after oxidative stress (2 mM H 2 O 2 ) applied in the early exponential (6 h) or early stationary (16 h) phase and in the presence or absence of MEL ( Figure 6 )

HMG-CoA reductase inhibitors are commonly used in the treatment of hyperlipidemia disorders but in addition have a plethora of vasculoprotective, anti-inflammatory and anti-fibrotic effects mediated by endothelial nitric oxide synthase (eNOS, NOS3) [207, 208]

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J Ethnopharmacol (2013) 145:62637