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Oxidative Medicine and Cellular Longevity , 2012, 324832

Additionally, Cbl deficiency has been associated with decreased immune function, such as reduced CD8 T cells and natural killer cells [29]

These include concerns regarding the long-term safety of gene modifications, challenges in the mass production of gene drugs, difficulties in controlling gene expression in vivo, limitations in achieving stable and long-term expression of foreign genes in vivo, low efficiency of targeted gene transfer, alterations in the biological properties of target cells, and ethical considerations