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( We further note that, consistent with section 1833(t)(6)(B)(iii) of the Act and 419.66(g), the period for which a device category for transitional pass-through payments under the OPPS can be in effect is at least 2 years, but not more than 3 years, beginning on the first date on which pass-through payment is made

Specifically, 2-O-methylation stabilizes helical regions [139, 140] and shifts the sugar pucker equilibrium toward the 3-endo conformation, which increases the overall rigidity of RNA duplexes [141, 142]

And while there's real science here, the conversation has become muddled

Moleiro J, Mo de Ferro S, Ferreira S, Serrano M, Silveira M, Dias Pereira A