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They concluded that: "Treatment with ARBs, such as telmisartan, or combined ARB and ACE2 [angiotensin converting enzyme 2] treatment represents a potential treatment strategy for dogs with DMVD and warrants additional preclinical study." Sacubitril/valsartan (Entresto, Sacufox V, Vymada, LCZ696) : Sacubitril/valsartan (Entresto, Sacufox V, Vymada, LCZ696) is a combination of valsartan , an angiotensin II receptor blocker (ARB), which prevents vasoconstriction thereby lowering blood pressure and improving blood flow

J Nutr, 2000