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Human research, though preliminary, shows encouraging results: PCOS patients taking curcumin (1,500 mg/day) for 12 weeks significantly lowered fasting blood glucose and insulin levels (237)

Available from: Chaker L, Bianco AC, Jonklaas J, et al

It has been shown that the maximum desired synergistic effect of the three components in the plant mixture depends on the accurate individual selection of the three components and their precise proportions, as determined in laboratory bioassays [52]

Moreover, some compounds may undergo bioactivation during Phase I metabolism, forming reactive intermediates that can cause adverse effects or contribute to toxicity