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Phase II trial of the autophagy inhibitor hydroxychloroquine with FOLFOX and bevacizumab in front line treatment of metastatic colorectal cancer

Immunosuppressive tumor microenvironments (Tmes) play a crucial role in determining the clinical outcomes of cancer therapies ( Figure 2 and Table 1 shows the roles of ferroptosis in overcoming drug resistance, strategies for overcoming cancer resistance and improving therapeutic efficacy by regulating cancer ferroptosis