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doi: 10.1104/pp.16.00273 177 VanderauweraS.VandenbrouckeK.InzA.Van De CotteB.MhlenbockP.De RyckeR.et al

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A pooled analysis of short-term randomized controlled trials indicated that vitamin C supplementation (median dose of 500 milligrams [mg]/day for a median duration of eight weeks) reduced blood pressure in both normotensive and hypertensive adults ( Table 3 )

Rather than acting through a single receptor or pathway, the peptide is thought to engage in a distributed mode of action, subtly shifting gene expression patterns toward a state associated with maintenance and adaptation