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Antioxidants, 10 (4), 520

5.3 TMAO and the inflammasome NLRP3 The activation of the NLRP3 inflammasome is a critical mediator of TMAO-induced pro-inflammatory effects

As a result, these models also show altered synaptic properties, pyramidal neuron disinhibition, and impaired locomotor coordination, underscoring the critical role of the GAD67-PV + IN pathway in GABAergic transmission and motor control [31, 42, 43, 63,64,65]