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Depletion of Cu using chelators has been shown to delay cancer metastasis by inhibiting the vascularization of lesions across several animal models, including a rabbit VX2 carcinoma model, 181 a mouse model of hepatocellular carcinoma, 182 and head and neck squamous cell carcinoma

10.1111/j.1471-4159.2004.02767.x 152 PasternakG

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