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Automated approach for the evaluation of glutathione-S-transferase P1-1 inhibition by organometallic anticancer compounds

Keeping optimal GSH:GSSG ratios is fundamental for cell survival, since GSH is one of the most important endogenous antioxidant defense systems, removing lipid- and hydrogen-peroxides [16]

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By using machine learning algorithms, we analyzed the 15 genes with LASSO logistic regression and SVM-RFE analysis, and five hub genes were identified to be significantly associated with ferroptosis, such as HIF1A , ACSL1 , CD82 , PEX2 and TFAP2A