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J Clin Invest 131

Before making the diagnosis of PFIC, in the paediatric population, other cholestasis disorders should always be considered in the differential diagnosis, including biliary atresia, choledochal malformations, congenital endocrine disorders, inborn errors of metabolism (mainly during the neonatal period) as well as autoimmune liver diseases, drug-induced cholestasis and other genetic diseases in older children [72]

importante distinguere tra la semplice riduzione del peso corporeo e il reale miglioramento della composizione corporea

Impaired fatty acid metabolism perpetuates lipotoxicity along the transition to chronic kidney injury