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Adding further complexity, TRIM21 utilizes K48 ubiquitination to degrade VDAC2 in nasopharyngeal carcinoma, suppressing cGAS/STING-mediated immune surveillance [12]

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Western blot analysis further confirmed SACs regulatory effects on the Keap1/Nrf2/GPX4 signaling pathway, showing elevated Nrf2, GPX4, NOQ1, HO1 and xCT protein levels and reduced Keap1 expression in the SAC group compared to the DSS group (Fig