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Its importance was first confirmed in the Arabidopsis mutants locking AtPCS1 activity, as these mutants show severe growth defects when challenged by heavy metals such as Cd 2+ , Hg 2+ , Zn 2+ , Pb 2+ , and As 3+ [28, 43, 44, 45]

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The results showed associations between polymorphisms of the GPIa/IIa, TNF-, MIF, and IL-10 genes and clinical and hematological alterations ( Dialogically, we have atovaquone, also from the naphthoquinones class, possessing the same mechanism found by Vale et al