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Several ferroptosis-associated genes, including ACSL4, acyl-CoA synthetase family member 2, GPX4, LPCAT3, NCOA4, solute carrier family 38, member 1 (SLC38A1) and glucose-6-phosphate dehydrogenase, all of which participate in the regulation of lipid or iron metabolism (10,67), have been shown to be markedly dysregulated (downregulated or upregulated) in UC specimens (5)

Safety studies To assess the cytotoxicity of MDMOC, CCK-8 method and live/dead cell staining were used to evaluate cell activity in HepG2 and LO-2 cells obtained from Wuhan Servicebio Technology Co., Ltd., Wuhan, China

Circulating CD11c+ B-cells include various subsets, notably age-related B-cells and IgDCD27 double-negative B-cells, which demonstrate a positive correlation with CHD severity (100)

Targeting SMYD2 promotes ferroptosis and impacts the progression of pancreatic cancer through the c-Myc/NCOA4 axis-mediated ferritinophagy