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10.1038/nphys3469

Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals

They are prescribed off-label by clinicians based on clinical judgment, existing research, and patient-specific factors

Senescent cells may also induce paracrine senescence in neighbouring cells by means of SASP factors release or via direct cellcell transfer of ROS through gap junctions, and their increase in both tumour and stromal senescent cells might underlay resistance to therapy 43