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DILI in Patients with Disease State Certain disease conditions may predispose individuals to DILI due to alterations in host immune function, drug metabolizing enzyme activity, lower serum albumin, glutathione reserve in the liver and overall ability to scavenge chemically reactive metabolites that can induce hepatotoxicity

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This is compounded by a high estimated prevalence of between 3.211.8%, being [4, 5] even greater in certain subgroups such as those with diabetes mellitus (20%) [6] and post radical prostatectomy (16%) [7]