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The principal regulatory mechanisms orchestrating ferroptosis encompass lipid peroxidation, amino acid metabolism, oxidative stress, iron ion homeostasis, and diverse organelles, all constituting prerequisites for the manifestation of ferroptosis to occur

Other studies have also shown that HIF-1 regulates the expression of certain cytochrome components directly and also regulates specific microRNAs that in turn regulate the expression of components of the electron transport chain [10,39,40]

Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort