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Description

The disruption of the interactions of CD23 with CD80 and CD86 by CTLA-4 leads to anergy, exhaustion and apoptosis of CTLs [33,45]

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NAD + degradation NAD + consumption As a co-substrate important to various postsynthesis modifications of fundamental macromolecules, NAD + can be cleaved by NAD + -consuming enzymes including PARPs, sirtuins, CD38 and SARM1 to generate NAM and ADP-ribose (ADPR) (Fig