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doi: 10.3389/fendo.2023.1133000 Received 28 December 2022 Accepted 13 March 2023 Published 24 March 2023 Volume 14 - 2023 Edited by Silvia Martina Ferrari, University of Pisa, Italy Reviewed by Sabrina Rosaria Paparo, University of Pisa, Italy

These mechanisms operate independently of caspases and represent unique therapeutic opportunities

He et al., 2022), and its phosphorylation allows it to bind microtubule-associated protein 1A/1B-light chain 3 (LC3), the adaptor protein that recruits cargo to the autophagosome (Lee and Lee, 2016)

When the liver is overloaded with FAs, it begins to store it as TGs resulting in steatosis (fat buildup) which is characteristic of MASLD [21, 22]