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Once it reaches the small intestine, enzymes called peptidases (proteins that break down other proteins) go to work

Further experiments showed that TGR5 activation could induce the transformation of M1 (inflammatory) to M2 (anti-inflammatory) macrophages and inhibit the differentiation of Th1 and Th17 cells (72)

With a well defined 24-hour circadian rhythm, cortisol levels are highest in the morning after about 30 minutes of waking up

the supporting literature also indicates that GSH has the ability to stem the lethal "cytokine storms" of rampant inflammation seen with anthrax toxins, smallpox vaccination complications, smallpox infections, and infections with Interleukin 4 (IL-4) enhanced smallpox and other "exotic microbes"