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In general, GPX4 homeostasis is affected by both selenocysteine biosynthesis/uptake ( 2.2 Lipid peroxidation Lipid peroxidation is a biomarker of ferroptosis ( 2.2.1 ACSL 4/LPCAT 3 A synthetase long-chain family (ACSL) is a major enzyme involved in lipid metabolism in vivo , notably facilitating the production of fatty acids with carbon chains ranging from 12 to 20 ( Meanwhile, ACSL4 is regulated by multiple factors, such as integrin 64-mediated inhibition of ACSL 4 expression by Src and signal transducer and activator of transcription 3 (STAT3) or activation of the androgen receptor ( LPCAT3 is a member of the LPLAT family of lysophospholipid acyltransferases