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the possible use, persistence, accumulation or degradation of the substance shows that there may be significant human or environmental exposure

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To validate this hypothesis, we calculated accumulation shift upon tolC deletion for combinations of these functional groups (Fig

*Correspondence: Zhongyan Shan, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers