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Peripheral inflammatory mediators may also activate the vagus nerve to transmit signals to the central nervous system (Capuron and Miller, 2011)

Adding the water-soluble glutathione tag marks these compounds for further processing through the mercapturic acid pathway and eventual excretion

Treatment with inactive, negative control compounds ( 11 and 12 ), structurally related to the active inhibitors 1 - 10 , had minimal effect on the GSH/GSSG in treated worms

NAC can inhibit ferroptosis by replenishing intracellular glutathione and supporting GPX4 activity, but its broad mechanism of action makes it difficult to attribute benefits specifically to ferroptosis inhibition ( Key hurdles for clinical translation of ferroptosis inhibitors include ( 5.2 Gut microbial modulators Understanding the role of gut microbiota in ferroptosis opens up exciting possibilities for new therapeutic strategies