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[11] This may be due to a corresponding genetic predisposition to sequestering ferritin in the liver or due to an increased sensitivity to ethanol ingestion [11, 12]

There were significant differences in the allelic frequency of GPX1 Pro198Leu (rs1050450) between the KBD and control group 67

In particular, the cystine/glutamate antiporter (System X c ), glutathione peroxidase 4 (GPX4) and glutathione (GSH) (System X c /GSH/GPX4 axis) plays a key role in preventing lipid peroxidation-mediated ferroptosis, because of which could be inhibited by blocking System X c /GSH/GPX4 axis

Probiotics, prebiotics, and synbiotics are under clinical investigation as adjunct therapies to modulate gut-brain interactions and reduce systemic inflammation (Chan et al., 2022