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Comparison of myo-inositol and metformin on glycemic control, lipid profiles, and gene expression related to insulin and lipid metabolism in women with polycystic ovary syndrome: a randomized controlled clinical trial

2.2.2 Mechanisms linking increased Hcy levels to MetS Elevated Hcy levels exert inhibitory effects on the insulin signaling pathway, primarily by inducing IR through the cysteine-homocysteinylation of the pro-insulin receptor

doi: 10.1073/pnas.0705306104

When your glutathione levels drop, you might notice darker spots on your skin, feel more tired than usual, or find that your body takes longer to recover from illness or stress