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Nitrosative stress-induced S-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response

Funding This research was financially supported by the University of Hong Kong (Project Number: 104006626), the Health@InnoHK programme from the Innovation and Technology Commission, Hong Kong SAR government, the Guangdong Basic and Applied Basic Research Foundation, China (2023B1515120035, 2024A1515012035) and the Science and Technology Planning Project of Guangdong Province, China (2020A0505100045)

Meanwhile, single-target strategies may provoke unwanted immune responses in the TME in certain cases, necessitating the further optimization of combination therapies