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Structural collagen changes, no

Cherny RA, Atwood CS, Xilinas ME, Gray DN, Jones WD, McLean CA, et al

The FDA moved these peptides to Category 2 primarily due to a lack of large-scale, randomized, placebo-controlled human trials demonstrating their safety and efficacy

This activity was characterized at the structural level by Kleinman and colleagues at the NIH and is the defining function of the parent Thymosin Beta-4 protein