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Various one-pot synthesis-based PROTACs with different aliphatic, aromatic and rigidified heterobifunctional linkers were synthesized, demonstrating the suitability of one-pot transformation for high-throughput screening

The disruption of intestinal barrier in DN The intestinal tract is the largest tissue and organ that absorb water and nutrients

In atherosclerotic cells, such as ox-LDL-treated macrophages, copper levels are significantly elevated (by approximately 62%), providing a catalyst for redox reactions [154]