glutathione synthetase deficiency testing Genetic Insights into Deficiency: Understanding the Role of Genetic REGULATION OF GLUTATHIONE SYNTHESIS -

Additionally, GPxs due to their subcellular compartmentalization (cytoplasmic, membrane, ER, and mitochondrial localizations) control the local concentration gradient of peroxides and thereby regulate the activation/deactivation of redox-responsive signaling pathways [1, 8,9,10]

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The primary structural difference between PfGST and other GST structures is the presence of an additional loop in the Plasmodium enzyme, connecting the alpha helix 4 to alpha helix 5 (residues 113-120) which are known to be involved in dimer formation and consequently in enzyme activity (Liebau et al., 2009)

But apart from that, there are two main things we should pay attention to: vitamin C and glutathione