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Whats more, the granular pigments named neuromelanin (NM) synthesized by DA in human SN has not been seen in the 2D-derived mDA neurons 28,29,30,31

Once released in the cytosol active p53 induces cellintrinsic apoptosis by activating a caspasedependent pathway likely involved in previously reported transcriptionindependent p53mediated apoptosis at the mitochondria Effectively, FOXO4-DRI is able to selectively penetrate the senescent cells without targeting healthy cells due to the use of D-amino acids instead of L-amino acids

[DOI] [PubMed] [Google Scholar] 111.Ninh NX

doi: 10.3390/ijms22168974 380 EeckhouteJOgerFStaelsBLefebvreP