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376 The causal role of oxidative damage in the ageing process remains controversial, partly because of the absence of a clear correlation between the efficacy of antioxidant defenses and extended cellular function or longevity

doi: 10.3390/biom14020198 17

59 MichaudM.MartinsI.SukkurwalaA

This phenomenon supports the notion that increased oxidative stress is an important pathogenic mechanism of HCC [2,3,5], and suggests that GSH might be utilized and oxidized to GSSG in order to cope with increased oxidative stress during the development of HCC