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Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the akt/GSK3-/NFAT Axis

Montes-Casado M, Sanvicente A, Casarrubios L, Feito MJ, Rojo JM, Vallet-Reg M, Arcos D, Portols P, Portols MT

CCI chronic contractile injury SNI spared nerve injury Fer-1 ferrostatin-1 Lip-1 liproxastin-1 GSH glutathione GPX4 glutathione peroxidase 4 ACSL4 acyl-CoA synthetase long-chain family member 4 SLC7A11 solute carrier family 7 member 11 ROS reactive oxygen species MDA malondialdehyde SOD superoxide dismutase DEmRNAs differentially expressed mRNAs DElncRNAs differentially expressed long noncoding RNAs CP/CPPS Chronic prostatitis/chronic pelvic pain syndrome Nrf2 nuclear factor erythroid 2-related factor 2 GAS gastrodin ECM extracellular matrix ssGSEA single-sample gene set enrichment analysis GCH1 GTP cyclohydrolase 1 SIRT2 sirtuin 2 DRG dorsal root ganglion FPN1 ferroportin 1 LDH lactate dehydrogenase CFA complete Freunds adjuvant DFO Iron chelator deferoxamine EDA free radical scavenger edaravone OA Osteoarthritis DEFRGs differentially expressed ferroptosis-related genes IVDD Intervertebral disc degeneration Abbreviations References 1 BiY.-H.WangJ.GuoZ.-J.JiaK.-N

K.GhoshdastidarB.GoyalG.BatinM.et al (2020)