gingivalis synergistically regulates three core pathways via the TLR4/NF-B signaling pathway: (1) iron metabolism imbalance (upregulation of TFRC and NCOA4 expression leading to intracellular iron overload), (2) lipid metabolism reprogramming (enhanced ACSL4 and LPCAT3 activity promoting polyunsaturated fatty acid phospholipid accumulation), (3) antioxidant defense collapse (downregulation of SLC7A11 and GPX4 triggering glutathione depletion and impaired lipid peroxide clearance)
Heliyon 9(7):e18069 Abu-Gharbieh E, Shehab NG, Almasri IM, Bustanji Y (2018) Antihyperuricemic and xanthine oxidase inhibitory activities of Tribulus arabicus and its isolated compound, ursolic acid: in vitro and in vivo investigation and docking simulations
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Biharee A, Chaudhari L, Bhartiya S et al (2024) A comprehensive study on natural products and their bioactive constituents to cure respiratory diseases
